Research Projects


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Research Overview

Our research interest is on interdisciplinary research covering two or more of the medical physics subfields (radiotherapy, diagnostic imaging, nuclear medicine, molecular imaging, radiobiology and nanotechnology) simultaneously in each project. Treatment verification of radiotherapy (proton and heavy ion therapy) and development of hybrid nanoparticles (for image- guided radiotherapy and molecular imaging applications) are two active research projects in our laboratory.

Our research projects are carried out as follows:

1) Monte Carlo simulations using OSU supercomputer clusters,

2) Instrumentation, fabrication, synthesis and cell/mouse preparation at Medical Physics Laboratory or other collaborator’s labs on the OSU campus,

3) Experiment – phantom study as well as in vitro (cell) and in vivo (animal) studies in collaborator cancer hospitals such as the University of Oklahoma Health Science Center, St. John Medical Center and MD Anderson Cancer Center

4) Imaging study using microPET/SPECT, human PET/SPECT and coincidence detectors.

 

We currently have seven active research projects.

1. Development of ultra-fast coincidence prompt gamma detectors for proton therapy verification.

2. Development of ultra-fast SPECT gamma camera for proton therapy verification.

3. Development of novel hybrid nanoparticles and quantum dots for image-guided radiosensitization/drug delivery and molecular imaging.

  • This project involves in-vitro and in-vivo imaging via optical/gamma detectors using              Cerenkov/fluorescence as well as PET/SPECT

4. Development of a novel proton spectrometer for more accurate LET and RBE calculation.

5. Development of patient implantable (hydrogel as well as silver) fiducial markers for proton treatment verification.

6. Development of 145Sm brachytherapy sources for gold nanoparticle mediated radiotherapy.

7. Gold nanoparticle mediated radiosensitization with radiotherapy.

 *Students and post-doctoral fellows with research interest outside the scope of the above projects are encouraged to contact us since we are open to explore various research projects that are important for cancer patient care.*